Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia

Zain M Virk; T Lee Richardson Jr; Joseph F Nowatzke; Asad Ullah; Dawn M Pedrotty; M Benjamin Shoemaker; Arvindh Kanagasundram; Dan M Roden; William G Stevenson

doi:10.1016/j.jaccas.2023.101878

Cardiac Sarcoidosis and a Likely Pathogenic TTN Variant in a Patient Presenting With Ventricular Tachycardia

JACC Case Rep. 2023 May 17:16:101878. doi: 10.1016/j.jaccas.2023.101878. eCollection 2023 Jun 21.

Authors

Zain M Virk¹, T Lee Richardson Jr¹, Joseph F Nowatzke¹, Asad Ullah², Dawn M Pedrotty¹, M Benjamin Shoemaker¹, Arvindh Kanagasundram¹, Dan M Roden¹, William G Stevenson¹

Affiliations

¹ Vanderbilt University Medical Center, Department of Medicine Division of Cardiology, Nashville, Tennessee, USA.
² Vanderbilt University Medical Center, Department of Pathology, Nashville, Tennessee, USA.

Abstract

Rare variants in TTN are the most common monogenic cause of early-onset atrial fibrillation and dilated cardiomyopathy. Whereas cardiac sarcoidosis is very underdiagnosed, a common presentation can be ventricular arrhythmias. This report presents a patient with a likely pathogenic TTN variant and cardiac sarcoidosis. (Level of Difficulty: Intermediate.).

Keywords: atrial fibrillation; cardiomyopathy; genetic disorders; imaging; ventricular tachycardia.

Publication types

Case Reports