DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition
Nature
.
2023 Jul;619(7968):E9-E18.
doi: 10.1038/s41586-023-06269-0.
Epub 2023 Jul 5.
Authors
Eikan Mishima
#
1
2
,
Toshitaka Nakamura
#
1
,
Jiashuo Zheng
#
1
,
Weijia Zhang
1
,
André Santos Dias Mourão
3
,
Peter Sennhenn
4
,
Marcus Conrad
5
Affiliations
1
Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.
2
Division of Nephrology, Rheumatology and Endocrinology, Tohoku University Graduate School of Medicine, Sendai, Japan.
3
Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.
4
transMedChem, Munich, Germany.
5
Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.
[email protected]
.
#
Contributed equally.
PMID:
37407687
DOI:
10.1038/s41586-023-06269-0
No abstract available
Publication types
Letter
Comment
MeSH terms
Dihydroorotate Dehydrogenase
Ferroptosis*
Humans
Neoplasms*
Substances
Dihydroorotate Dehydrogenase