Mechanisms of hypoxaemia in severe pulmonary hypertension associated with COPD

Lucilla Piccari; Isabel Blanco; Yolanda Torralba; Ebymar Arismendi; Concepción Gistau; Ana Ramírez; Elena Gimeno-Santos; Josep Roca; Felip Burgos; Roberto Rodríguez-Roisín; Joan Albert Barberà

doi:10.1183/13993003.00463-2023

Mechanisms of hypoxaemia in severe pulmonary hypertension associated with COPD

Eur Respir J. 2023 Jul 20;62(1):2300463. doi: 10.1183/13993003.00463-2023. Print 2023 Jul.

Authors

Lucilla Piccari¹, Isabel Blanco^{2

3

4}, Yolanda Torralba^{1

3

4}, Ebymar Arismendi^{1

3

4}, Concepción Gistau¹, Ana Ramírez¹, Elena Gimeno-Santos^{1

3}, Josep Roca^{1

3

4}, Felip Burgos^{1

3

4}, Roberto Rodríguez-Roisín^{1

3

4}, Joan Albert Barberà^{1

3

4}

Affiliations

¹ Department of Pulmonary Medicine, Hospital Clínic, University of Barcelona, Barcelona, Spain.
² Department of Pulmonary Medicine, Hospital Clínic, University of Barcelona, Barcelona, Spain [email protected].
³ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
⁴ Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Madrid, Spain.

Abstract

Severe hypoxaemia, characteristic of COPD with severe pulmonary hypertension, is due to a combination of greater ventilation–perfusion mismatch, increased intrapulmonary shunt and reduced P_vO₂, with negligible hypoxic pulmonary vasoconstriction regulation https://bit.ly/3Wnzpik

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Hypertension, Pulmonary* / complications
Hypoxia / complications
Oxygen
Pulmonary Disease, Chronic Obstructive* / complications
Respiration Disorders* / complications

Substances

Oxygen