Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease

Alex Kayongo; Brian Nyiro; Trishul Siddharthan; Bruce Kirenga; William Checkley; Moses Lutaakome Joloba; Jerrold Ellner; Padmini Salgame

doi:10.3389/fcimb.2023.1146571

Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease

Front Cell Infect Microbiol. 2023 Jun 21:13:1146571. doi: 10.3389/fcimb.2023.1146571. eCollection 2023.

Authors

Alex Kayongo^{1

2

3}, Brian Nyiro^{1

2}, Trishul Siddharthan⁴, Bruce Kirenga³, William Checkley^{5

6}, Moses Lutaakome Joloba³, Jerrold Ellner¹, Padmini Salgame¹

Affiliations

¹ Department of Medicine, Center for Emerging Pathogens, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States.
² Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda.
³ Makerere University College of Health Sciences, Lung Institute, Makerere University, Kampala, Uganda.
⁴ Division of Pulmonary and Critical Care Medicine, University of Miami, Miami, FL, United States.
⁵ Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
⁶ Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.

Abstract

Pulmonary tuberculosis is increasingly recognized as a risk factor for COPD. Severe lung function impairment has been reported in post-TB patients. Despite increasing evidence to support the association between TB and COPD, only a few studies describe the immunological basis of COPD among TB patients following successful treatment completion. In this review, we draw on well-elaborated Mycobacterium tuberculosis-induced immune mechanisms in the lungs to highlight shared mechanisms for COPD pathogenesis in the setting of tuberculosis disease. We further examine how such mechanisms could be exploited to guide COPD therapeutics.

Keywords: COPD - chronic obstructive pulmonary disease; Tuberculosis; adaptive immunity; host-directed therapy (HDT); innate immunity.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Humans
Lung / microbiology
Mycobacterium tuberculosis*
Pulmonary Disease, Chronic Obstructive* / complications
Tuberculosis*
Tuberculosis, Pulmonary* / microbiology

Abstract

Publication types

MeSH terms

Grants and funding