Duffy-Null Phenotype-Associated Neutropenia is the Most Common Etiology for Leukopenia/Neutropenia Referrals to a Tertiary Children's Hospital

Kelsey Gay; Kristopher Dulay; Yaddanapudi Ravindranath; Süreyya Savaşan

doi:10.1016/j.jpeds.2023.113608

Duffy-Null Phenotype-Associated Neutropenia is the Most Common Etiology for Leukopenia/Neutropenia Referrals to a Tertiary Children's Hospital

J Pediatr. 2023 Nov:262:113608. doi: 10.1016/j.jpeds.2023.113608. Epub 2023 Jul 6.

Authors

Kelsey Gay¹, Kristopher Dulay², Yaddanapudi Ravindranath³, Süreyya Savaşan⁴

Affiliations

¹ Children's Hospital of Michigan, Detroit, MI; Penn State Children's Hospital, Hershey, PA.
² Division of Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI.
³ Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
⁴ Division of Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI; Division of Hematology/Oncology, Pediatric Blood and Marrow Transplant Program, Barbara Ann Karmanos Cancer Center, Children's Hospital of Michigan, Detroit, MI; Department of Pediatrics, Central Michigan University College of Medicine, Mount Pleasant, MI. Electronic address: [email protected].

PMID: 37419240
DOI: 10.1016/j.jpeds.2023.113608

Abstract

Duffy-null phenotype-associated neutropenia was present in 77.7% of leukopenia/neutropenia referrals to our center in Detroit with a high prevalence in Yemeni (96.6%), African American (91%), and non-Yemeni Middle Eastern (52.9%) patients. Greater availability of Duffy typing in patients with neutropenia but without recurrent/frequent/serious infections may lessen the need for additional consultations and investigations.

Keywords: African; Duffy-null phenotype; Middle Eastern; Yemeni; benign ethnic neutropenia.

MeSH terms

Child
Duffy Blood-Group System* / genetics
Hospitals
Humans
Neutropenia* / genetics
Phenotype
Referral and Consultation

Substances

Duffy Blood-Group System