Background and Update for ECOG-ACRIN EA8212: A Randomized Phase 3 Trial of Intravesical Bacillus Calmette-Guérin (BCG) Versus Intravesical Docetaxel and Gemcitabine Treatment in BCG-naïve High-grade Non-muscle-invasive Bladder Cancer (BRIDGE)

Eur Urol Focus. 2023 Jul;9(4):561-563. doi: 10.1016/j.euf.2023.06.006. Epub 2023 Jul 6.

Abstract

EA8212 BRIDGE is a phase 3 randomized trial comparing BCG vs GemDoce for BCG naïve high-risk non-muscle-invasive bladder cancer. This article provides an explanation for the rationale of the clinical trial and details the study design.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Administration, Intravesical
  • BCG Vaccine / therapeutic use
  • Clinical Trials, Phase III as Topic
  • Docetaxel / therapeutic use
  • Gemcitabine
  • Humans
  • Non-Muscle Invasive Bladder Neoplasms*
  • Randomized Controlled Trials as Topic
  • Urinary Bladder Neoplasms* / drug therapy

Substances

  • BCG Vaccine
  • Docetaxel
  • Gemcitabine