Objective: To evaluate the influence of sperm from different sources in intrauterine insemination on clinical and neonatal outcomes.
Methods: We retrospectively analyzed the clinical and follow-up data on 1,071 cases of singleton pregnancy by IUI at the Center of Assisted Reproduction of our hospital from January 2015 to December 2017. According to the sources of sperm, 658 of the pregnancies were achieved by artificial insemination by donor (AID) and the other 413 by artificial insemination by husband (AIH). We compared the clinical parameters between the two groups.
Results: No statistically significant differences were observed between the AID and AIH groups in spontaneous abortion (76 ［11.55%］ vs 60 ［14.53%］, P > 0.05), <37 wk premature delivery (20 ［3.48%］ vs16 ［4.65%］, P > 0.05), mean birth weight (［3.33 ± 0.46］ vs ［3.30 ± 0.48］ kg, P > 0.05), <2.5 kg low birth weight (15 ［2.61%］ vs 13 ［3.78%］, P > 0.05), ≥4.0 kg fetal macrosomia (41 ［7.13%］ vs 31 ［9.01%］, P > 0.05), or fetal defects (6 ［1.04%］ vs 4 ［1.16%］, P > 0.05).
Conclusions: Artificial insemination by donor does not increase the risk of adverse clinical and neonatal outcomes and therefore is considered as a safe and reliable assisted reproductive technique.
Keywords: artificial insemination by husband; neonatal outcomes; singleton pregnancy; artificial insemination by donor.