Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions

Vet Clin North Am Equine Pract. 2023 Dec;39(3):565-578. doi: 10.1016/j.cveq.2023.06.005. Epub 2023 Jul 11.

Abstract

Increasing antimicrobial resistance in veterinary practice has driven the investigation of novel therapeutic strategies including regenerative and biologic therapies to treat bacterial infection. Integration of biological approaches such as platelet lysate and mesenchymal stromal cell (MSC) therapy may represent adjunctive treatment strategies for bacterial infections that minimize systemic side effects and local tissue toxicity associated with traditional antibiotics and that are not subject to antibiotic resistance. In this review, we will discuss mechanisms by which biological therapies exert antimicrobial effects, as well as potential applications and challenges in clinical implementation in equine practice.

Keywords: Antimicrobial; Biologic; Horse; Mesenchymal stromal cells; Platelets; Regenerative; Therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents
  • Blood Platelets
  • Horse Diseases* / therapy
  • Horses
  • Mesenchymal Stem Cells*

Substances

  • Anti-Bacterial Agents