Community Versus Vertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study

Daniele De Luca; Elizabeth Perkins; David G Tingay; European Society of Pediatric and Neonatal Intensive Care COVID-19 Paediatric and Neonatal Registry Group; European society of pediatric and neonatal intensive care covid-19 paediatric and neonatal registry (EPICENTRE) group - group authorship; European Society of Pediatric and Neonatal Intensive Care COVID-19 Paediatric and Neonatal Registry Group and European society of pediatric and neonatal intensive care covid-19 paediatric and neonatal registry (EPICENTRE) group - group authorship

doi:10.1097/INF.0000000000003950

Community Versus Vertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study

Pediatr Infect Dis J. 2023 Aug 1;42(8):685-687. doi: 10.1097/INF.0000000000003950. Epub 2023 Apr 18.

Authors

Daniele De Luca^{1

2}, Elizabeth Perkins^{3

4}, David G Tingay^{3

4}; European Society of Pediatric and Neonatal Intensive Care COVID-19 Paediatric and Neonatal Registry Group; European society of pediatric and neonatal intensive care covid-19 paediatric and neonatal registry (EPICENTRE) group - group authorship; European Society of Pediatric and Neonatal Intensive Care COVID-19 Paediatric and Neonatal Registry Group and European society of pediatric and neonatal intensive care covid-19 paediatric and neonatal registry (EPICENTRE) group - group authorship

Collaborators

Danilo Buonsenso⁵, Roberta Centorrino, Alexandre Vivanti⁶, Shancy Rooze⁷, Francisco J Pilar-Orive⁸, Walusa Assad Gonçalves-Ferri⁹, Angela Amigoni¹⁰, Werther Brunow de Carvalho¹¹, Vera Lucia Jornada Krebs¹², Niran Al-Naqeeb¹³, Olivier Danhaive¹⁴, Merih Cetinkaya¹⁵, Howard Stein¹⁶, Jessica Shoemaker¹⁶, Olivier Danhaive¹⁴, Paul Torpiano¹⁷, Susanne Vetter-Laracy¹⁸, Bjarte Rogdo¹⁹, Yasser Elsayed²⁰, Giovanna Chidini²¹, Martin Kneyber²², Alberto Medina Villanueva²³, Angelo Polito²⁴, Carole Nm Brouwer²⁵, Peter Rimensberger²⁴

Affiliations

¹ From the Division of Pediatrics and Neonatal Critical Care, "A.Beclere" Medical Center, Paris Saclay University Hospitals, APHP, Paris, France.
² Physiopathology and therapeutic innovation Unit-INSERM U999, Paris Saclay University, Paris, France.
³ Neonatal Research, Murdoch Children's Research Institute, Parkville, Australia.
⁴ Department of Paediatrics, University of Melbourne, Melbourne, Australia.
⁵ Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
⁶ "Antoine Béclère" Medical Centre, Paris Saclay University Hospitals, APHP, France.
⁷ Hôpital Universitaire des enfants Reine Fabiola, Unités de soins intensifs, Laeken, Belgique.
⁸ Pediatrics Department - PICU, Biocruces Bizkaia Health Research Institute Cruces University Hospital, Barakaldo, Spain.
⁹ Department of Pediatrics, Ribeirão Preto Medical School - University of São Paulo, São Paulo State, Ribeirão Preto, Brazil.
¹⁰ Department of Pediatrics, Pediatric Intensive Care Unit, University Hospital of Padova, Padova, Italy.
¹¹ Pediatric Intensive Care/Neonatology of the Department of Pediatrics, Faculty of Medicine - University of São Paulo, São Paulo, Brazil.
¹² Division of Neonatology, Department of Pediatrics, Faculty of Medicine - University of São Paulo, São Paulo, Brazil.
¹³ Neonatal Department, AL-Adan Hospital, Ahmadi Area, Kuwait.
¹⁴ Division of Neonatology (Pediatrics), Catholic University of Louvain, Brussels, Belgium.
¹⁵ Department of Neonatology, Basaksehir, Cam and Sakura City Hospital, Istanbul, Turkey.
¹⁶ Division of Neonatology, Department of Pediatrics, Promedica Ebied Children's Hospital, Toledo, OH, USA.
¹⁷ Department of Paediatrics and Adolescent Health, Mater Dei Hospital, Msida, Malta.
¹⁸ University Hospital Son Espases/Balearic Island Health Research Institute - IdISBa, Palma, Spain.
¹⁹ NICU/PICU, Children's Hospital of Eastern Switzerland, St Gallen, Switzerland.
²⁰ Section of Neonatology, Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
²¹ Department of Anesthesia and Intensive Care, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Pediatric Intensive Care Unit, Milan, Italy.
²² Division of Paediatric Critical Care Medicine, Department of Paediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Netherlands.
²³ Pediatric Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain.
²⁴ Pediatric and Neonatal Intensive Care Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
²⁵ Pediatric Intensive Care Unit, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

Neonatal Severe Acute Respiratory Syndrome-CoronaVirus-2 infections can be community-acquired or vertically-acquired. The analysis of neonatal patients requiring hospitalization reported in the EPICENTRE worldwide registry shows that community-acquired cases have clinical features (fever, respiratory signs, feeding difficulties, P < 0.0001) and received antibiotics (P = 0.014) more frequently than vertically-acquired patients. Severe Acute Respiratory Syndrome-CoronaVirus-2 infections should be considered in the clinical workout of neonatal infections.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19*
Cohort Studies
Humans
Infant, Newborn
SARS-CoV-2