Induction chemotherapy-based organ-preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer-Results of a matched-pair analysis

Yifan Yang; Ling Feng; Qi Zhong; Yang Zhang; Zhigang Huang; Shurong Zhang; Shuling Li; Junmao Gao; Lizhen Hou; Hongzhi Ma; Shizhi He; Qian Shi; Meng Lian; Yanming Zhao; Xixi Shen; Jiaming Chen; Lingwa Wang; Haiyang Li; Shaoshi Chen; Jiaqi Xu; Ru Wang; Jugao Fang

doi:10.1002/cam4.6354

Induction chemotherapy-based organ-preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer-Results of a matched-pair analysis

Cancer Med. 2023 Aug;12(16):17078-17086. doi: 10.1002/cam4.6354. Epub 2023 Jul 19.

Authors

Yifan Yang^{1

2}, Ling Feng^{1

2}, Qi Zhong^{1

2}, Yang Zhang^{1

2}, Zhigang Huang^{1

2}, Shurong Zhang³, Shuling Li⁴, Junmao Gao⁵, Lizhen Hou^{1

2}, Hongzhi Ma^{1

2}, Shizhi He^{1

2}, Qian Shi^{1

2}, Meng Lian^{1

2}, Yanming Zhao^{1

2}, Xixi Shen^{1

2}, Jiaming Chen^{1

2}, Lingwa Wang^{1

2}, Haiyang Li^{1

2}, Shaoshi Chen^{1

2}, Jiaqi Xu^{1

2}, Ru Wang^{1

2}, Jugao Fang^{1

2}

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.
² Key Laboratory of Otorhinolaryngology, Head and Neck Surgery, Beijing Institute of Otorhinolaryngology, Beijing, China.
³ Department of Oncology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.
⁴ Department of Radiology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.
⁵ Department of Radiotherapy, Seventh Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing, China.

Abstract

Background: We performed a paired analysis to compare the therapeutic effect between the induction chemotherapy-based organ-preservation approach and immediate total laryngectomy in hypopharyngeal squamous cell carcinoma patients requiring total laryngectomy.

Methods: 351 patients who were treated with organ-preservation approach were compared with 110 patients who were treated with total laryngectomy. The main measures and outcomes were progression-free survival (PFS), overall survival (OS), and larynx function preservation survival (LFPS).

Results: No statistical difference was observed for 3-, 5-, and 10-year PFS and OS in two groups. In the organ-preservation group, the 3-, 5-, and 10-year LFPS was 30.7%, 23.3%, and 16.6%, respectively. The LFPS of Stage III > Stage IV, N0 > N1 > N2 > N3, T2 > T3 > T4, CR > PR > SD > PD patients (all p values <0.05).

Conclusions: Survival outcomes did not significantly differ between the two groups. The organ-preservation approach allowed more than 70% of the survivors to retain their larynx function.

Keywords: chemotherapy; hypopharyngeal cancer; laryngectomy; organ preservation; surgery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Head and Neck Neoplasms* / pathology
Humans
Hypopharyngeal Neoplasms* / drug therapy
Hypopharyngeal Neoplasms* / surgery
Induction Chemotherapy / methods
Laryngeal Neoplasms* / drug therapy
Laryngeal Neoplasms* / surgery
Laryngectomy / methods
Matched-Pair Analysis
Neoplasm Staging
Retrospective Studies