Aggressive SM + AML has limited therapeutic options. Even a strong combination of decitabine-venetoclax-midostaurin has a transient effect on AML and a mitigated effect on SM. Larger series are required to identify the best therapeutic strategy.
Keywords: HAM regimen; advanced systemic mastocytosis (AdvSM); cladribine; concurrent hematologic disease; decitabine–venetoclax (DEC‐VEN); refractory acute myeloid leukemia (R‐AML).
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