HPV-associated oropharyngeal Adenosquamous carcinoma with early metastatic disease detected by ctDNA

Samantha Newman; J Harrison Cowart; Nivin Omar; Elizabeth Martin; J Kenneth Byrd

doi:10.1016/j.oraloncology.2023.106526

HPV-associated oropharyngeal Adenosquamous carcinoma with early metastatic disease detected by ctDNA

Oral Oncol. 2023 Oct:145:106526. doi: 10.1016/j.oraloncology.2023.106526. Epub 2023 Jul 21.

Authors

Samantha Newman¹, J Harrison Cowart¹, Nivin Omar², Elizabeth Martin³, J Kenneth Byrd⁴

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Medical College of Georgia at Augusta University, Augusta, GA, United States.
² Department of Pathology, Medical College of Georgia at Augusta University, Augusta GA, United States.
³ Department of Pathology and Lab Medicine, West Virginia University Health Sciences Center, Morgantown, WV, United States.
⁴ Department of Otolaryngology Head and Neck Surgery, Medical College of Georgia at Augusta University, Augusta, GA, United States. Electronic address: [email protected].

PMID: 37482044
DOI: 10.1016/j.oraloncology.2023.106526

Abstract

Adenosquamous Carcinoma is a rare, aggresssive variant of squamous cell carcinoma that may HPV-driven in the oropharynx. Although it is reported to behave similar to HPV-related squamous cell carcinoma, the literature is very limited for this disease. We present a case of early T and N stage HPV + adenosquamous carcinoma of the tonsil that metastasized immediately following surgery and adjuvant therapy despite only having microscopic nodal burden. Circulating tumor DNA (ctDNA) was instrumental in recognizing and salvaging metastatic disease early with radiation.

Publication types

Case Reports
Letter

MeSH terms

Carcinoma, Adenosquamous*
Carcinoma, Squamous Cell* / pathology
Humans
Neoplasms, Second Primary*
Oropharyngeal Neoplasms*
Palatine Tonsil / pathology
Papillomaviridae / genetics
Papillomavirus Infections* / complications
Papillomavirus Infections* / pathology