Objective: To understand the infection status and epidemiological characteristics of hepatitis C in people aged 1-69 years in Henan Province in 2020. Methods: The estimated sample size was 5 827. From August to December 2020, multistage sampling was used to select 8 counties (districts) in Henan, and two survey sites were selected in each county (district), and a questionnaire survey was conducted in local people aged 1-69 years, blood samples were collected from them for anti-HCV, HCV RNA and genotype detections. Results: A total of 5 165 people aged 1-69 years completed the questionnaire survey. Men accounted for 44.76% (2 312/5 165), women accounted for 55.24% (2 853/5 165). In the people aged 1-69 years, the overall prevalence rates of anti-HCV and HCV RNA were 0.69% (95%CI: 0.68%-0.70%) and 0.20% (95%CI: 0.19%-0.21%) respectively. The prevalence rates of anti-HCV and HCV RNA were 0.48% (95%CI: 0.46%-0.50%), 0.09% (95%CI: 0.08%-0.10%) in men and 0.86% (95%CI: 0.85%-0.87%), 0.30% (95%CI: 0.28%-0.32%) in women. The prevalence rates of anti-HCV and HCV RNA increased with age. The prevalence rates of anti-HCV and HCV RNA were 0.87% (95%CI: 0.86%-0.88%), 0.28% (95%CI: 0.26%-0.30%) in urban residents and 0.53% (95%CI: 0.51%-0.55%), 0.14% (95%CI: 0.13%-0.15%) in rural residents. The genotyping results of 10 HCV RNA positive samples ware genotype 1b (4/10), genotype 2 (3/10), genotype 1b/3 (1/10), genotype 1b/3/6 (1/10) and genotype 2/6 (1/10). Conclusions: The prevalence of hepatitis C was low in Henan in 2020. It is necessary to strengthen hepatitis C surveillance in people aged 40 years and above. The major HCV genotypes were 1b and 2, and mixed genotype infection existed.
目的： 了解2020年河南省1~69岁人群丙型肝炎（丙肝）流行状况和特征。 方法： 估计样本量为5 827人。采用多阶段抽样，于2020年8-12月在河南省抽取8个县（区），每个县（区）抽取2个调查点，对1~69岁的人群进行问卷调查，并采集静脉血液标本进行HCV抗体、核酸和基因型检测。 结果： 调查5 165人，其中男性占44.76%（2 312/5 165），女性占55.24%（2 853/5 165）。1~69岁的人群抗-HCV、HCV RNA调整阳性率分别为0.69%（95%CI：0.68%~0.70%）和0.20%（95%CI：0.19%~0.21%）。男性抗-HCV和HCV RNA调整阳性率分别为0.48%（95%CI：0.46%~0.50%）和0.09%（95%CI：0.08%~0.10%）；女性为0.86%（95%CI：0.85%~0.87%）和0.30%（95%CI：0.28%~0.32%）。抗-HCV和HCV RNA阳性率均呈随年龄增长而增加的趋势。城市人群抗-HCV和HCV RNA调整阳性率分别为0.87%（95%CI：0.86%~0.88%）和0.28%（95%CI：0.26%~0.30%）；农村为0.53%（95%CI：0.51%~0.55%）和0.14%（95%CI：0.13%~0.15%）。10人HCV RNA阳性样本的基因型分别为1b型（4/10）、2型（3/10）、1b/3型（1/10）、1b/3/6型（1/10）和2/6型（1/10）。 结论： 2020年河南省丙肝流行率较低，年龄≥40岁是开展丙肝监测工作的重点人群。HCV基因型以1b型和2型为主，存在混合基因型感染情况。.