Sex Differences in the Neurobiology of Stress

Hannah Stadtler; Gretchen N Neigh

doi:10.1016/j.psc.2023.04.002

Sex Differences in the Neurobiology of Stress

Psychiatr Clin North Am. 2023 Sep;46(3):427-446. doi: 10.1016/j.psc.2023.04.002. Epub 2023 May 29.

Authors

Hannah Stadtler¹, Gretchen N Neigh²

Affiliations

¹ Department of Anatomy and Neurobiology, 1101 East Marshall Street Box 980709, Virginia Commonwealth University, Richmond, VA, USA.
² Department of Anatomy and Neurobiology, 1101 East Marshall Street Box 980709, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: [email protected].

PMID: 37500242
DOI: 10.1016/j.psc.2023.04.002

Abstract

This review highlights the existing knowledge and data that explain the physiologic impacts of stress, especially pertaining to neurobiology, and how these impacts differ by sex. Furthermore, this review explains the benefits of interventions aimed at preventing or mitigating the adverse effects of stress, because of both the significant toll of stress on the body and the disproportionate impact of these changes experienced by women.

Keywords: Estrogen; Neurobiology; Sex differences; Stress; Stress-mitigating interventions.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Female
Humans
Male
Neurobiology*
Sex Characteristics*

Grants and funding

U54 AG062334/AG/NIA NIH HHS/United States