MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience

Yoichi Muramoto; Naoya Murakami; Tatsuki Karino; Satoru Sugimoto; Jun Takatsu; Masaki Oshima; Yasuo Kosugi; Terufumi Kawamoto; Takashi Hirayama; Kazunari Fujino; Yasuhisa Terao; Naoto Shikama

doi:10.1016/j.ctro.2023.100659

MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience

Clin Transl Radiat Oncol. 2023 Jul 17:42:100659. doi: 10.1016/j.ctro.2023.100659. eCollection 2023 Sep.

Affiliations

¹ Department of Radiation Oncology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan.
² Department of Obstetrics and Gynecology, Juntendo University Hospital, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan.

Abstract

We first used MucoUp®, a hyaluronic acid used in endoscopic resection, as a spacer in brachytherapy. In five cervical cancer patients, MucoUp® insertion increased a 90% dose of the high-risk CTV to over 80 Gy while decreasing the dose of organs at risk. No related adverse events were observed.

Keywords: Brachytherapy; MucoUp®; Spacer; Uterine cervical cancer.