Comparison of dental anesthetic efficacy between the periodontal intraligamentary anesthesia and other infiltration anesthesia: a systematic review and meta-analysis

Jialei Pan; Yan Wang; Yuran Qian; Jing Zou; Qiong Zhang

doi:10.7717/peerj.15734

Comparison of dental anesthetic efficacy between the periodontal intraligamentary anesthesia and other infiltration anesthesia: a systematic review and meta-analysis

PeerJ. 2023 Jul 24:11:e15734. doi: 10.7717/peerj.15734. eCollection 2023.

Authors

Jialei Pan^#¹, Yan Wang^#², Yuran Qian³, Jing Zou², Qiong Zhang²

Affiliations

¹ Sichuan University, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chengdu, China.
² Sichuan University, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Chengdu, China.
³ Sichuan University, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Chengdu, China.

^# Contributed equally.

Abstract

Background: Uncertainty exists regarding the pain scores and the success rate of intraligamentary anesthesia compared to other infiltration anesthesia. Based on the conditions of clinical anesthesia techniques, we conducted a systematic review and meta-analysis to compare the efficacy of intraligamentary anesthesia with other infiltration anesthesia.

Methods: The search was carried out in PubMed Central, Cochrane Central Register of Controlled Trials, MEDLINE (via OVID), Embase (via OVID), and Scopus from the inception to March 26, 2023.

Results: Seven eligible randomized controlled trials were included in the meta-analysis. The results indicated no significant difference in the success rate (RR = 0.96; 95% CI [0.81-1.14]; p = 0.65; I²= 73%) and visual analog scale (VAS) during dental procedures (MD = 3.81; 95% CI [-0.54-8.16]; p = 0.09; I²= 97%) between intraligamentary anesthesia and other infiltration anesthesia. However, intraligamentary anesthesia exhibited a higher VAS score during injection than other infiltration anesthesia (MD = 8.83; 95% CI [4.86-12.79]; p < 0.0001; I²= 90%). A subgroup analysis according to infiltration techniques showed that supraperiosteal anesthesia had a lower VAS score during dental procedures than intraligamentary anesthesia.

Conclusions: Intraligamentary anesthesia and other infiltration anesthesias have the same success rate and pain during dental procedures. However, the pain during injection of intraligamentary anesthesia is heavier than that of other infiltration anesthesia.

Keywords: Dental local anesthesia; Infiltration anesthesia; Intraligamentary injection.

Publication types

Meta-Analysis
Systematic Review
Research Support, Non-U.S. Gov't

MeSH terms

Anesthesia, Local* / methods
Anesthetics, Local*
Humans
Injections
Pain
Pain Measurement / methods

Substances

Anesthetics, Local

Grants and funding

This study was supported by the Natural Science Foundation of Sichuan Province 2022NSFSC1482 (Yan Wang) and 2023NSFSC1509 (Qiong Zhang). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.