A novel digital approach for post-stroke cognitive deficits: a pilot study

Massimiliano Oliveri; Sergio Bagnato; Silvia Rizzo; Emilia Imbornone; Andreina Giustiniani; Angela Catania; Patrizia Turriziani

doi:10.3233/RNN-231305

A novel digital approach for post-stroke cognitive deficits: a pilot study

Restor Neurol Neurosci. 2023;41(3-4):103-113. doi: 10.3233/RNN-231305.

Authors

Massimiliano Oliveri¹, Sergio Bagnato², Silvia Rizzo², Emilia Imbornone², Andreina Giustiniani³, Angela Catania^{1

4

5}, Patrizia Turriziani⁴

Affiliations

¹ Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy.
² Rehabilitation Department, Unit of Neurophysiology and Unit for Severe Acquired Brain Injuries, Giuseppe Giglio Foundation, Cefalù, Italy.
³ IRCCS San Camillo Hospital, Venice, Italy.
⁴ Laboratory of Neuropsychology, Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.
⁵ International School of Advanced Studies, University of Camerino, Camerino, Italy.

PMID: 37522228
DOI: 10.3233/RNN-231305

Abstract

Background: Cognitive dysfunctions after a brain stroke have a huge impact on patients' disability and activities of daily living. Prism adaptation (PA) is currently used in patients with right brain damage to improve lateralized spatial attentional deficits. Recent findings suggest that PA could also be useful for rehabilitation of other cognitive functions.

Objective: In the present study, we tested for the efficacy on cognitive rehabilitation of a novel device in which the procedure of prism adaptation is digitized and followed by cognitive training of attention and executive functions using serious games.

Methods: Thirty stroke patients were randomly assigned to two groups: an experimental group of 15 patients, which performed the experimental rehabilitation training using the novel device in 10 consecutive daily sessions; a control group of 15 patients, which performed the routine cognitive training in 10 consecutive daily sessions. Both groups were tested before and after the rehabilitation program on neuropsychological tests (digit and spatial span forward and backward, attentional matrices, Stroop task) and on functional scales (Barthel index and Beck Anxiety Index).

Results: The main results showed that only patients who received the experimental rehabilitation training improved their scores on tests of digit span forward, spatial span backward, attentional matrices and Stroop. Moreover, patients of the experimental but not of the control group showed a significant correlation between improvement on some tasks (mainly spatial span backward) and improvement on activities of daily living as well as with reduction of anxiety levels.

Conclusions: These results suggest that combining digital PA with cognitive training using serious games may be added in clinical settings for cognitive rehabilitation of stroke patients, with beneficial effects extending in promoting independency in activities of daily living and reduction of psychiatric symptoms.

Keywords: Stroke; cognition; digital medicine; prism adaptation; rehabilitation.

Publication types

Randomized Controlled Trial

MeSH terms

Activities of Daily Living
Cognition
Cognitive Dysfunction* / etiology
Cognitive Dysfunction* / therapy
Humans
Pilot Projects
Stroke Rehabilitation* / methods
Stroke*