Late complications after allogeneic hematopoietic cell transplant: What primary care physicians can do

Lauren M Granat; Mariah Ondeck; Bennett Osantowski; Michael Sheu; Vishwanath Ganesan; Seth Rotz; Betty K Hamilton

doi:10.3949/ccjm.90a.23006

Late complications after allogeneic hematopoietic cell transplant: What primary care physicians can do

Cleve Clin J Med. 2023 Aug 1;90(8):499-508. doi: 10.3949/ccjm.90a.23006.

Authors

Lauren M Granat¹, Mariah Ondeck², Bennett Osantowski², Michael Sheu², Vishwanath Ganesan², Seth Rotz³, Betty K Hamilton⁴

Affiliations

¹ Chief Resident, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH [email protected].
² PGY3, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH.
³ Staff Physician, Department of Pediatric Hematology, Oncology, and Blood and Marrow Transplant, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
⁴ Staff Physician, Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; Associate Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.

PMID: 37527880
DOI: 10.3949/ccjm.90a.23006

Abstract

Survivors of allogeneic hematopoietic cell transplant (HCT) face the risk of many serious complications in the long term, which primary care physicians play an integral role in recognizing and treating. In this review, the authors summarize the most common complications that primary care physicians see after HCT recipients return to their care: chronic graft-vs-host disease; cardiovascular, metabolic, endocrine, rheumatologic, orthopedic, infectious, neurologic, and cognitive complications; secondary malignancies; psychiatric disorders; and impairments in quality of life and sexual health. Also discussed are health maintenance and screening recommendations for this patient population.

Publication types

Review

MeSH terms

Bronchiolitis Obliterans Syndrome*
Graft vs Host Disease* / diagnosis
Graft vs Host Disease* / etiology
Graft vs Host Disease* / prevention & control
Hematopoietic Stem Cell Transplantation* / adverse effects
Humans
Physicians, Primary Care*
Quality of Life