Hydrogenation reactions are staple transformations commonly used across scientific fields to synthesise pharmaceuticals, natural products, and various functional materials. However, the vast majority of these reactions require the use of a toxic and costly catalyst leading to unpractical, hazardous and often functionally limited conditions. Herein, we report a new, general, practical, efficient, mild and high-yielding hydrogen-free electrochemical method for the reduction of alkene, alkyne, nitro and azido groups. Finally, this method has been applied to deuterium labelling.
Keywords: Anodic Oxidation; Deuteration; Diimide Reduction; Electrochemistry; Hydrogenation.
© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.