Macropinocytosis: Blowing bubbles

Joel A Swanson

doi:10.1016/j.cub.2023.06.053

Macropinocytosis: Blowing bubbles

Curr Biol. 2023 Aug 7;33(15):R812-R814. doi: 10.1016/j.cub.2023.06.053.

Author

Joel A Swanson¹

Affiliation

¹ Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5620, USA. Electronic address: [email protected].

PMID: 37552948
DOI: 10.1016/j.cub.2023.06.053

Abstract

Macropinocytosis is a form of endocytosis in which cells engulf relatively large quantities of extracellular fluid through cup-shaped invaginations of the plasma membrane. New work shows that macropinosome closure occurs without a localized constriction of actin filaments, indicating that membrane tension drives cup closure.

Publication types

Comment

MeSH terms

Actin Cytoskeleton
Cell Membrane
Endocytosis*
Endosomes
Pinocytosis*