Preparation strategy of hydrogel microsphere and its application in skin repair

Honggang Chi; Yunqi Qiu; Xiaoqing Ye; Jielin Shi; Ziyi Li

doi:10.3389/fbioe.2023.1239183

Preparation strategy of hydrogel microsphere and its application in skin repair

Front Bioeng Biotechnol. 2023 Jul 24:11:1239183. doi: 10.3389/fbioe.2023.1239183. eCollection 2023.

Authors

Honggang Chi^{1

2}, Yunqi Qiu¹, Xiaoqing Ye¹, Jielin Shi¹, Ziyi Li^{1

2}

Affiliations

¹ The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China.
² The Second Clinical Medical College, Guangdong Medical University, Dongguan, China.

Abstract

In recent years, hydrogel microsphere has attracted much attention due to its great potential in the field of skin repair. This paper reviewed the recent progress in the preparation strategy of hydrogel microsphere and its application in skin repair. In this review, several preparation methods of hydrogel microsphere were summarized in detail. In addition, the related research progress of hydrogel microspheres for skin repair was reviewed, and focused on the application of bioactive microspheres, antibacterial microspheres, hemostatic microspheres, and hydrogel microspheres as delivery platforms (hydrogel microspheres as a microcarrier of drugs, bioactive factors, or cells) in the field of skin repair. Finally, the limitations and future prospects of the development of hydrogel microspheres and its application in the field of skin repair were presented. It is hoped that this review can provide a valuable reference for the development of the preparation strategy of hydrogel microspheres and promote the application of hydrogel microspheres in skin repair.

Keywords: antibacterial microsphere; bioactive microsphere; functional microsphere; hemostatic microsphere; hydrogel microsphere; skin repair.

Publication types

Review

Grants and funding

The work was supported by the Funds for Guangdong Basic and Applied Basic Research Foundation (2023A1515010012), Dongguan Science and Technology of Social Development Program (20221800905632), PHD researchers of Guangdong Medical University (No. 4SG22222G), College Students’ Innovation Training Project in Guangdong Medical University (Nos GDMU2022040, GDMU2022094), and the College Students Innovative Experimental Project in Guangdong Medical University (Nos ZYDC002, ZYDM009, FZDB005).