Spatial immune profiling of glioblastoma identifies an inflammatory, perivascular phenotype associated with longer survival
Acta Neuropathol
.
2023 Oct;146(4):647-649.
doi: 10.1007/s00401-023-02617-6.
Epub 2023 Aug 13.
Authors
Hans-Georg Wirsching
1
,
Jörg Felsberg
2
,
Michael Prummer
3
,
Vlad Moisoiu
4
,
Roxanne Lourman
4
,
Caroline Hertler
5
,
Michelle Antonios
4
,
Patrick J Cimino
6
,
Patrick Roth
4
,
Thierry Gorlia
7
,
Robert M Prins
8
,
Timothy Cloughesy
8
,
Patrick Y Wen
9
,
Eric C Holland
10
,
Guido Reifenberger
2
11
,
Michael Weller
4
Affiliations
1
Department of Neurology, University Hospital and University of Zurich, Frauenklinikstrasse 26, CH-8091, Zurich, Switzerland.
[email protected]
.
2
Institute of Neuropathology, Medical Faculty, Heinrich Heine University and University Hospital Düsseldorf, Düsseldorf, Germany.
3
NEXUS Personalized Health Technologies and Swiss Institute of Bioinformatics, ETH Zurich, Zurich, Switzerland.
4
Department of Neurology, University Hospital and University of Zurich, Frauenklinikstrasse 26, CH-8091, Zurich, Switzerland.
5
Department of Radiation Oncology, Competence Center for Palliative Care, University Hospital and University of Zurich, Zurich, Switzerland.
6
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
7
European Organization for Research and Treatment of Cancer, Brussels, Belgium.
8
Department of Neurosurgery, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
9
Center for Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
10
Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
11
Partner Site Essen/Düsseldorf, German Cancer Consortium (DKTK), Düsseldorf, Germany.
PMID:
37573572
PMCID:
PMC10499942
DOI:
10.1007/s00401-023-02617-6
No abstract available
Publication types
Research Support, Non-U.S. Gov't
MeSH terms
Brain Neoplasms* / genetics
Glioblastoma* / genetics
Humans
Phenotype
Grants and funding
R35 CA253119/CA/NCI NIH HHS/United States