Prognostic value of insulin resistance and hyperglycemia biomarkers for long-term risks of cardiometabolic outcomes

J Diabetes Complications. 2023 Sep;37(9):108583. doi: 10.1016/j.jdiacomp.2023.108583. Epub 2023 Aug 2.

¹ Department of Epidemiology and Welch Center for Prevention, Epidemiology, & Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: [email protected].
² Department of Epidemiology and Welch Center for Prevention, Epidemiology, & Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
³ Division of General Internal Medicine, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, United States.
⁴ Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States.

Abstract

We found that individuals in the top tertile of HOMA-IR and with HbA1c-defined prediabetes have elevated risk of cardiometabolic outcomes.

Keywords: Biomarkers; Cardiometabolic disease; Insulin resistance; Prediabetes; Prospective cohort.