Spinocerebellar ataxia type 1: It's not just about Purkinje cells

Puneet Opal

doi:10.1016/j.neuron.2023.07.014

Spinocerebellar ataxia type 1: It's not just about Purkinje cells

Neuron. 2023 Aug 16;111(16):2461-2462. doi: 10.1016/j.neuron.2023.07.014.

Author

Puneet Opal¹

Affiliation

¹ Davee Department of Neurology and Department of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: [email protected].

PMID: 37591199
DOI: 10.1016/j.neuron.2023.07.014

Abstract

In this issue of Neuron, Pilotto et al.¹ use state-of-the-art in vivo imaging in mice to show that excitatory/inhibitory imbalance drives SCA1 pathophysiology, with hyperexcitable molecular layer interneurons overinhibiting Purkinje cells, leading to hallmark neurodegeneration.

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MeSH terms

Animals
Interneurons
Mice
Neurons
Purkinje Cells*
Spinocerebellar Ataxias* / genetics