BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Blood. 2023 Nov 2;142(18):1570-1575. doi: 10.1182/blood.2023021212.

Abstract

In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Histiocytosis, Langerhans-Cell* / epidemiology
  • Histiocytosis, Langerhans-Cell* / genetics
  • Histiocytosis, Langerhans-Cell* / pathology
  • Humans
  • Incidence
  • Mutation
  • Neoplasms, Second Primary* / epidemiology
  • Neoplasms, Second Primary* / genetics
  • Proto-Oncogene Proteins B-raf / genetics
  • Retrospective Studies

Substances

  • Proto-Oncogene Proteins B-raf
  • BRAF protein, human