Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression

Chaofeng Tu; Junfei Wen; Weili Wang; Qifan Zhu; Ying Chen; Jianglu Cheng; Zeye Li; Lanlan Meng; Yong Li; Wenbin He; Chen Tan; Chunbo Xie; Shao-Mei Fu; Juan Du; Guangxiu Lu; Ge Lin; Lan-Tao Gou; Yue-Qiu Tan

doi:10.1038/s41421-023-00580-w

Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression

Cell Discov. 2023 Aug 22;9(1):87. doi: 10.1038/s41421-023-00580-w.

Authors

Chaofeng Tu^#^{1

2}, Junfei Wen^#^{3

4}, Weili Wang^#^{1

2

5}, Qifan Zhu^#^{3

4}, Ying Chen^{3

6}, Jianglu Cheng^{3

4}, Zeye Li^{3

4}, Lanlan Meng^{1

2}, Yong Li¹, Wenbin He², Chen Tan¹, Chunbo Xie^{1

2}, Shao-Mei Fu⁷, Juan Du^{1

2}, Guangxiu Lu², Ge Lin^{8

9}, Lan-Tao Gou^{10

11}, Yue-Qiu Tan^{12

13

14}

Affiliations

¹ Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
² Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China.
³ State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
⁴ University of Chinese Academy of Sciences, Beijing, China.
⁵ College of Life Science, Hunan Normal University, Changsha, Hunan, China.
⁶ Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, China.
⁷ Department of Breast Surgeon, The Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China.
⁸ Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China. [email protected].
⁹ Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China. [email protected].
¹⁰ State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China. [email protected].
¹¹ University of Chinese Academy of Sciences, Beijing, China. [email protected].
¹² Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China. [email protected].
¹³ Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China. [email protected].
¹⁴ College of Life Science, Hunan Normal University, Changsha, Hunan, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter