The analysis of multiple outcomes, multiple variables and variables selection in hematopoietic cell transplantation studies

Best Pract Res Clin Haematol. 2023 Sep;36(3):101478. doi: 10.1016/j.beha.2023.101478. Epub 2023 May 24.

Abstract

It is common to study time-to-event data in cancer research such as hematopoietic cell transplantation (HCT) for leukemia. The extensive work has been done for the univariate survival outcome, that is, one event type. However, in practice a subject is often exposed to multiple types of outcomes. In this article, we review various types of right-censored data with multiple outcome types including competing risks data, recurrent event data, and composite endpoints. We also provide hematopoietic cell transplantation data examples.

Keywords: Competing risks; Composite endpoints; Recurrent events; Variable selection.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Leukemia*