The Role of Poly(ADP-ribose) Polymerase 1 in Nuclear and Mitochondrial Base Excision Repair

Geoffrey K Herrmann; Y Whitney Yin

doi:10.3390/biom13081195

The Role of Poly(ADP-ribose) Polymerase 1 in Nuclear and Mitochondrial Base Excision Repair

Biomolecules. 2023 Jul 31;13(8):1195. doi: 10.3390/biom13081195.

Authors

Geoffrey K Herrmann^{1

2}, Y Whitney Yin^{1

2}

Affiliations

¹ Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
² Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Abstract

Poly(ADP-ribose) (PAR) Polymerase 1 (PARP-1), also known as ADP-ribosyl transferase with diphtheria toxin homology 1 (ARTD-1), is a critical player in DNA damage repair, during which it catalyzes the ADP ribosylation of self and target enzymes. While the nuclear localization of PARP-1 has been well established, recent studies also suggest its mitochondrial localization. In this review, we summarize the differences between mitochondrial and nuclear Base Excision Repair (BER) pathways, the involvement of PARP-1 in mitochondrial and nuclear BER, and its functional interplay with other BER enzymes.

Keywords: DNA repair; PARP-1; nuclear and mitochondrial localization.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

DNA Repair*
Mitochondria
Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerase Inhibitors*

Substances

Poly(ADP-ribose) Polymerase Inhibitors
Poly Adenosine Diphosphate Ribose

Abstract

Publication types

MeSH terms

Substances

Grants and funding