Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease

Javaria Baig; Neha Sawant; Priyanka Rawat; Arubala P Reddy; P Hemachandra Reddy; Sudhir Kshirsagar

doi:10.1016/j.bbadis.2023.166858

Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease

Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166858. doi: 10.1016/j.bbadis.2023.166858. Epub 2023 Aug 25.

Authors

Javaria Baig¹, Neha Sawant¹, Priyanka Rawat¹, Arubala P Reddy², P Hemachandra Reddy³, Sudhir Kshirsagar⁴

Affiliations

¹ Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
² Nutritional Sciences Department, College of Human Sciences, Texas Tech University, 1301 Akron Ave, Lubbock, TX 79409, USA.
³ Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Nutritional Sciences Department, College of Human Sciences, Texas Tech University, 1301 Akron Ave, Lubbock, TX 79409, USA; Neurology, Departments of School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Public Health Department of Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Speech, Language and Hearing Sciences, School Health Professions, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: [email protected].
⁴ Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: [email protected].

PMID: 37633469
DOI: 10.1016/j.bbadis.2023.166858

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that affects a large proportion of the aging population. RalBP1 (Rlip) is a stress-activated protein, that plays an important role in aging and neurodegenerative diseases such as Alzheimer's disease. Mutant APP and mutant Tau interact with the Rlip protein which leads to decreased wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease. Rlip is a promising new target for aging, Alzheimer's disease, and other neurological diseases.

Keywords: Alzheimer's disease; Mitochondrial dysfunction; Oxidative stress; Rlip protein.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alzheimer Disease* / genetics
Alzheimer Disease* / metabolism
Humans
Neurodegenerative Diseases*

Substances

RALBP1 protein, human
MAPT protein, human
APP protein, human