Proof of Concept for Continuous On-Demand Phrenic Nerve Stimulation to Prevent Diaphragm Disuse during Mechanical Ventilation (STIMULUS): A Phase 1 Clinical Trial

Idunn S Morris; Thiago Bassi; Catherine A Bellissimo; Marc de Perrot; Laura Donahoe; Laurent Brochard; Nawzer Mehta; Viral Thakkar; Niall D Ferguson; Ewan C Goligher

doi:10.1164/rccm.202305-0791LE

Proof of Concept for Continuous On-Demand Phrenic Nerve Stimulation to Prevent Diaphragm Disuse during Mechanical Ventilation (STIMULUS): A Phase 1 Clinical Trial

Am J Respir Crit Care Med. 2023 Nov 1;208(9):992-995. doi: 10.1164/rccm.202305-0791LE.

Authors

Idunn S Morris^{1

2

3

4}, Thiago Bassi^{3

5}, Catherine A Bellissimo⁶, Marc de Perrot⁷, Laura Donahoe⁷, Laurent Brochard^{1

8}, Nawzer Mehta⁵, Viral Thakkar⁵, Niall D Ferguson^{1

2

9

3

6}, Ewan C Goligher^{1

2

3

6}

Affiliations

¹ Interdepartmental Division of Critical Care Medicine.
² Department of Physiology, and.
³ Division of Respirology, Department of Medicine, and.
⁴ Department of Intensive Care Medicine, Nepean Hospital, Sydney, New South Wales, Australia.
⁵ Lungpacer Medical USA Inc., Exton, Pennsylvania.
⁶ Toronto General Hospital Research Institute, Toronto, Ontario, Canada; and.
⁷ Division of Thoracic Surgery, Department of Surgery, University Health Network, Toronto, Ontario, Canada.
⁸ Keenan Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
⁹ Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.

PMID: 37642635
DOI: 10.1164/rccm.202305-0791LE

No abstract available

Publication types

Clinical Trial, Phase I
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Diaphragm / innervation
Electric Stimulation Therapy*
Electrodes, Implanted
Humans
Phrenic Nerve
Proof of Concept Study
Respiration, Artificial* / adverse effects
Thorax