Quantitative evaluation of the clinical severity of hemoglobin H disease in a cohort of 591 patients using a scoring system based on regression analysis

Affiliations

• ¹ Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong.
• ² Department of Medical Genetics and Prenatal Diagnosis, Huizhou First Maternal and Child Health Care Hospital, Huizhou, Guangdong, 516001.
• ³ Department of Pediatric Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120.
• ⁴ Department of Hematology, 923(rd) Hospital of the People's Liberation Army, Nanning, Guangxi 530021.
• ⁵ Guangzhou Huayin Healthcare Group Co., Ltd., Guangzhou 510663, Guangdong, China; Guangzhou Jiexu Gene Technology Co., Ltd., Guangzhou 510530, Guangdong.
• ⁶ Prenatal Diagnosis Center, Chenzhou First People's Hospital Chenzhou 423000, Hunan.
• ⁷ Department of Laboratory Hematology, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi.
• ⁸ Department of Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi.
• ⁹ Department of Hematology and Rheumatology, Longyan First Hospital, Affiliated to Fujian Medical University, Longyan 364000.
• ¹⁰ Department of Medical Dispute, Maternal and Child Health Hospital, Heyuan517000.
• ¹¹ Maternal and Child Health Hospital of Yongzhou City, Yongzhou, Hunan 425000.
• ¹² Biologics,Gene and Cell Therapy, Frontage Laboratories, 760 Pennsylvania Dr, Exton, PA, 19341.
• ¹³ Department of Hematology, 923(rd) Hospital of the People's Liberation Army, Nanning, Guangxi 530021. [email protected].
• ¹⁴ Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong. [email protected].
• ¹⁵ Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong. [email protected].