A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S

Affiliations

• ¹ Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA. [email protected].
• ² Department of Medicine, Harvard Medical School, Boston, MA, USA. [email protected].
• ³ CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA. [email protected].
• ⁴ Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
• ⁵ Department of Medicine, Harvard Medical School, Boston, MA, USA.
• ⁶ Institute of Gerontology, Wayne State University, Detroit, MI, USA.
• ⁷ Department of Neurosciences, University of California San Diego, San Diego, CA, USA.
• ⁸ Albert Einstein College of Medicine, Bronx, NY, USA.
• ⁹ Department of Medicine, Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.
• ¹⁰ Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, IL, USA.
• ¹¹ Department of Epidemiology & Population Health, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
• ¹² Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• ¹³ Department of Neurology, University of California at Davis, Sacramento, CA, USA.
• ¹⁴ Shiley-Marcos Alzheimer's Disease Center, University of California San Diego, La Jolla, CA, USA.
• ¹⁵ Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.