Introduction: Holoprosencephaly (HPE) is a complex brain malformation resulting from a medial cleavage defect of the prosencephalon into right and left hemispheres, occurring during early embryonic development.
Case presentation: We report an alobar holoprosencephaly diagnosed on imaging (obstetrical ultrasound) and revealed by a polymalformative syndrome in an 8-month-old infant.
Discussion: Holoprosencephaly affects the forebrain and face, causing neurological manifestations and facial anomalies of varying severity. HPE is a cerebral midline anomaly.
Conclusion: Its fetal prognosis is extremely guarded, particularly for the alobar form.
Keywords: Brain; Fetal malformation; Holoprosencephaly.
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