Which trial do we need? A sequential multiple assignment randomized trial to determine the optimal Clostridioides difficile treatment sequence

Affiliations

• ¹ Department of Medical Microbiology, Centre for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands; ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Study Group for Clostridioides Difficile (ESGCD), Basel, Switzerland; ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Study Group for Host and Microbiota Interaction (ESGHAMI), Basel, Switzerland. Electronic address: [email protected].
• ² Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
• ³ Department of Research and Medicine, Edward Hines Jr Veterans Administration Hospital, Hines, IL, USA; Loyola University Medical Center, Department of Medicine, Maywood, IL, USA.
• ⁴ ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Study Group for Clostridioides Difficile (ESGCD), Basel, Switzerland; ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Study Group for Host and Microbiota Interaction (ESGHAMI), Basel, Switzerland; Department of Medicine, Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland.
• ⁵ ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Study Group for Clostridioides Difficile (ESGCD), Basel, Switzerland; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
• ⁶ Department of Medical Microbiology, Centre for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands; ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Study Group for Clostridioides Difficile (ESGCD), Basel, Switzerland; ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Study Group for Host and Microbiota Interaction (ESGHAMI), Basel, Switzerland.