Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease

Affiliations

• ¹ Laboratory of Clinical Investigations, National Institutes of Aging, Baltimore, Md.
• ² Division of Molecular Genetics and Pathology, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Md; Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
• ³ Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
• ⁴ Translational Hepatology Section, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Md.
• ⁵ Department of Biochemistry and Molecular Pharmacology, New York University Langone Health, New York, NY.
• ⁶ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio.
• ⁷ Department of Pediatric Gastroenterology, Mayo Clinic, Rochester, Minn.
• ⁸ Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Mass; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medical College, New York, NY.
• ⁹ Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Mass.
• ¹⁰ National Human Genome Research Institute (NHGRI), NIH, Bethesda, Md.
• ¹¹ Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, Md.
• ¹² Bioinformatics Core, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
• ¹³ Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, Md.
• ¹⁴ Immune Deficiency-Cellular Therapy Program, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, Md.
• ¹⁵ Division of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, Wis.
• ¹⁶ Division of Allergy, Immunology, and Transplantation, NIAID, NIH, Bethesda, Md.
• ¹⁷ Department of Pediatrics, University of Washington School of Medicine and Seattle Children's Hospital and Research Center, Seattle, Wash.
• ¹⁸ Department of Pediatrics, Duke University Medical Center, Durham, NC.
• ¹⁹ Division of Hematology, Oncology, and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, Calif.
• ²⁰ Division of Allergy and Immunology, Children's Hospital of Philadelphia and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.
• ²¹ Division of Blood and Marrow Transplantation and Cellular Therapies, University of Pittsburgh Medical Center (UPMC) and Children's Hospital of Pittsburgh, Pittsburgh, Pa.
• ²² Department of Pediatrics, Harvard University Medical School, Boston, Mass.
• ²³ Section of Hematology/Immunology, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.
• ²⁴ Intermountain Primary Children's Hospital, University of Utah, Salt Lake City, Utah.
• ²⁵ Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
• ²⁶ Division of Pediatric Hematology-Oncology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wis.
• ²⁷ Center for Cell and Gene Therapy for Non-Malignant Conditions, Johns Hopkins All Children's Hospital, St Petersburg, Fla.
• ²⁸ Division of Allergy and Immunology, UPMC, Children's Hospital of Pittsburgh, Pittsburgh, Pa.
• ²⁹ Division of Immunology and Allergy, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
• ³⁰ Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii; University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, Hawaii.
• ³¹ Fred Hutchinson Cancer Research Center, Seattle, Wash.
• ³² Cincinnati Children's Hospital Medical Center, and University of Cincinnati, Cincinnati, Ohio.
• ³³ Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga.
• ³⁴ Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada; Department of Microbiology, Infectious Diseases, and Immunology, Université de Montréal, Montreal, Quebec, Canada.
• ³⁵ University of California San Francisco Benioff Children's Hospital, San Francisco, Calif.
• ³⁶ Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Calif.
• ³⁷ Division of Pediatric Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute at the University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, Utah.
• ³⁸ Allen Institute for Immunology, Seattle, Wash.
• ³⁹ Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
• ⁴⁰ Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md; Department of Microbiology, Infectious Diseases, and Immunology, Université de Montréal, Montreal, Quebec, Canada; Center for Immunity, Inflammation and Infectious Diseases, IRCM, Montreal, Quebec, Canada; Department of Medicine, Université de Montréal, Montreal, Quebec, Canada. Electronic address: [email protected].