The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Jéssica Manoelli Costa Silva; Eliel Barbosa Teixeira; Ronald Matheus da Silva Mourão; Rafaella Sousa Ferraz; Fabiano Cordeiro Moreira; Paulo Pimentel de Assumpção; Danielle Queiroz Calcagno

doi:10.3389/fphar.2023.1237723

The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Front Pharmacol. 2023 Aug 21:14:1237723. doi: 10.3389/fphar.2023.1237723. eCollection 2023.

Authors

Jéssica Manoelli Costa Silva¹, Eliel Barbosa Teixeira¹, Ronald Matheus da Silva Mourão¹, Rafaella Sousa Ferraz², Fabiano Cordeiro Moreira¹, Paulo Pimentel de Assumpção¹, Danielle Queiroz Calcagno¹

Affiliations

¹ Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, Brazil.
² Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belem, Pará, Brazil.

Abstract

Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.

Keywords: biomarkers; gastric cancer; gastric carcinogenesis; historical overview; long non-coding RNAs; molecular mechanisms.

Publication types

Review

Grants and funding

This study was Financially supported by Universidade Federal do Pará, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; to JS, ET, and RM) and Conselho Nacional de Desenvolvimento Científico e Tecnologia (CNPq; to DC, 313127/2020-4, PP, 313303/2021-5, and RF.