Vaccination in post-tuberculosis lung disease management: A review of the evidence

M J Nasiri; D R Silva; F Rommasi; M M Zahmatkesh; Z Tajabadi; F Khelghati; T Sarmastzadeh; R Centis; L D'Ambrosio; S Bombarda; M P Dalcolmo; T Galvão; F C de Queiroz Mello; M F Rabahi; E Pontali; I Solovic; M Tadolini; L Marconi; S Tiberi; M van den Boom; G Sotgiu; G B Migliori

doi:10.1016/j.pulmoe.2023.07.002

Vaccination in post-tuberculosis lung disease management: A review of the evidence

Pulmonology. 2023 Sep 5:S2531-0437(23)00129-0. doi: 10.1016/j.pulmoe.2023.07.002. Online ahead of print.

Authors

M J Nasiri¹, D R Silva², F Rommasi¹, M M Zahmatkesh¹, Z Tajabadi¹, F Khelghati¹, T Sarmastzadeh¹, R Centis³, L D'Ambrosio⁴, S Bombarda⁵, M P Dalcolmo⁶, T Galvão⁷, F C de Queiroz Mello⁸, M F Rabahi⁹, E Pontali¹⁰, I Solovic¹¹, M Tadolini¹², L Marconi¹³, S Tiberi¹⁴, M van den Boom¹⁵, G Sotgiu¹⁶, G B Migliori¹⁷

Affiliations

¹ Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
³ Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy.
⁴ Public Health Consulting Group, Lugano, Switzerland.
⁵ Secretaria de Estado da Saúde de São Paulo, Programa de Controle da Tuberculose, São Paulo, Brazil.
⁶ Reference Center Hélio Fraga, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.
⁷ Serviço de Pneumologia, Hospital Especializado Octávio Mangabeira, Secretaria de Saúde do Estado da Bahia, Salvador, Brazil.
⁸ Thorax Diseases Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
⁹ Faculdade de Medicina, Universidade Federal de Goiás (UFG), Goiânia, Brazil.
¹⁰ Department of Infectious Diseases, Galliera Hospital, Genoa, Italy.
¹¹ Department of Public Health, Faculty of Health, Catholic University, Ruzomberok, Slovakia; National Institute of Tuberculosis, Pulmonary Diseases and Thoracic Surgery, Vysne Hagy, Slovakia.
¹² Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
¹³ Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
¹⁴ Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, E1 2AT United Kingdom.
¹⁵ World Health Organisation, Regional Office for the Eastern Mediterranean Region, Cairo, Egypt.
¹⁶ Clinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Italy.
¹⁷ Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. Electronic address: [email protected].

PMID: 37679219
DOI: 10.1016/j.pulmoe.2023.07.002

Abstract

Introduction and objectives: Post-tuberculosis lung disease (PTLD), as other chronic respiratory disorders, may have infectious complications; some of them can be prevented with vaccinations. So far, no document has discussed the potential role of vaccination in PTLD. Therefore, the objective of this review was to describe vaccination recommendations to prevent infections potentially capable of complicating PTLD.

Materials and methods: A non-systematic review of the literature was conducted. The following keywords were used: tuberculosis, vaccination, vaccines and PTLD. PubMed/MEDLINE and Embase were used as the search engine, focusing on English-language literature only.

Results: We identified 9 vaccines potentially useful in PTLD. Influenza, pneumococcal and anti-COVID-19 vaccinations should be recommended. Patients with PTLD can also benefit from vaccination against shingles. Vaccination against pertussis is mainly relevant during childhood. Diphtheria, tetanus and measles vaccination are recommended for general population and should be considered in patients with PTLD not previously vaccinated. Tdap (Tetanus, diphtheria, and pertussis) booster should be repeated in every adult every ten years. Vaccination against BCG retains its importance during early childhood in countries where TB is endemic.

Conclusions: Vaccination deserves to be considered among the strategies to prevent and/or mitigate PTLD complications. Further evidence is necessary to better understand which vaccines have the greatest impact and cost-benefit.

Keywords: Mycobacterium tuberculosis; Post-tuberculosis lung disease; Respiratory infections; Vaccination.

Publication types

Review

Grants and funding

001/WHO_/World Health Organization/International