Role for cell death pathway in Alzheimer's disease

Science. 2023 Sep 15;381(6663):1156-1157. doi: 10.1126/science.adk2009. Epub 2023 Sep 14.

Authors

Daniel W Sirkis¹, Jennifer S Yokoyama^{1

2}

Affiliations

¹ Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
² Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

PMID: 37708264
DOI: 10.1126/science.adk2009

Abstract

Human neurons transplanted into mice with amyloid plaques die by necroptosis.

MeSH terms

Alzheimer Disease* / pathology
Animals
Humans
Mice
Necroptosis*
Neurons / pathology
Neurons / transplantation
Plaque, Amyloid* / pathology