Stem cell-like memory T (TSCM) cell is a memory T cell subset with characteristics of long life span, consistent self-renewing, and the multipotent capacity to reconstitute the memory and effector T cell subsets. TSCM cell is the least differentiated cell in the memory T lymphocyte system, endowed with the stem cell-like ability, and it is essential for maintaining functional immunity. In addition, owing to its robust potential for immune reconstitution, it is central player in many physiological and pathological human processes. TSCM cell plays an important role in the occurrence and development of various autoimmune diseases. The specific role of TSCM cell in autoimmune diseases may make it a potential target for the treatment of multiple autoimmune diseases, driving effective immune reconstitution in therapy.
干细胞样记忆T(stem cell-like memory T，TSCM)细胞是一种长寿的、具有持续自我更新能力及重建记忆、效应T细胞亚群的多分化潜能的记忆T细胞亚群，是记忆T细胞系统中的最小分化细胞，具有类似干细胞的生物学特征，对于维持功能性免疫至关重要。由于TSCM细胞强大的免疫重建功能，它在人类的许多病理和生理过程中发挥着核心作用，在多种自身免疫性疾病的发生及发展中起重要作用。TSCM细胞在自身免疫性疾病中的独特作用可能使其成为治疗多种自身免疫性疾病的潜在靶点，可在相关疾病治疗中进行有效的免疫功能重建。.
Keywords: autoimmune diseases; cell differentiation; immunotherapy; stem cell-like memory T cell.