The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

Curr Opin Pharmacol. 2023 Dec:73:102404. doi: 10.1016/j.coph.2023.102404. Epub 2023 Sep 19.

Abstract

Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.

Keywords: ATP; COVID-19; Connexin; Gap junctions; Hemichannels; NeuroHIV.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • COVID-19*
  • Connexins
  • HIV Infections* / drug therapy
  • Humans
  • Receptors, Purinergic / metabolism
  • SARS-CoV-2

Substances

  • Connexins
  • Receptors, Purinergic
  • Adenosine Triphosphate