Pre-chronic obstructive pulmonary disease (Pre-COPD) refers to individuals with chronic respiratory symptoms, structural abnormalities, and/or functional abnormalities, in the absence of airflow limitation, who may develop persistent airflow limitation over time. COPD is characterized by high prevalence and great heterogeneity and complexity. Early multidimensional identification and promotion of early prevention, management and treatment of Pre-COPD can help delay or halt the development of COPD, which has significant public health implications. This review aimed to summarize the definition, relevant cohorts, clinical trials, and other research progress in pre-COPD in order to improve the understanding of individuals with pre-COPD and improve early prevention and management of COPD.
慢性阻塞性肺疾病（简称慢阻肺）前期（pre-COPD）是指存在慢性呼吸道症状、肺部结构改变和（或）病理生理学改变，但肺通气功能尚未达到慢阻肺诊断标准（吸入支气管舒张剂后FEV1/FVC<0.70），在后续随访中更易进展为慢阻肺的人群。慢阻肺前期发生率高，存在较大的异质性和复杂性。因此，多维度精准辨析慢阻肺前期的发生发展，加强慢阻肺前期的防控与诊治，可能有助于延缓甚至阻断慢阻肺的发生发展，减轻慢阻肺相关的疾病负担，具有重大的公共卫生意义。因此本文对慢阻肺前期的定义、相关队列和临床试验等研究进展进行综述，以提高对慢阻肺前期人群的认识，进一步提升慢阻肺的早期防控水平。.