Endogenous inhibitory mechanisms in asthma

Sergio E Chiarella; Peter J Barnes

doi:10.1016/j.jacig.2023.100135

Endogenous inhibitory mechanisms in asthma

J Allergy Clin Immunol Glob. 2023 Jul 5;2(4):100135. doi: 10.1016/j.jacig.2023.100135. eCollection 2023 Nov.

Authors

Sergio E Chiarella¹, Peter J Barnes²

Affiliations

¹ Division of Allergic Diseases, Mayo Clinic, Rochester.
² National Heart and Lung Institute, Imperial College London.

Abstract

Endogenous inhibitory mechanisms promote resolution of inflammation, enhance tissue repair and integrity, and promote homeostasis in the lung. These mechanisms include steroid hormones, regulatory T cells, IL-10, prostaglandin E₂, prostaglandin I₂, lipoxins, resolvins, protectins, maresins, glucagon-like peptide-1 receptor, adrenomedullin, nitric oxide, and carbon monoxide. Here we review the most recent literature regarding these endogenous inhibitory mechanisms in asthma, which remain a promising target for the prevention and treatment of asthma.

Keywords: Asthma; IL-10; Treg cell; adrenomedullin; airway inflammation; carbon monoxide; endogenous; glucagon-like peptide-1 receptor; inhibition; inhibitory; lipoxin; maresin; mechanism; nitric oxide; pathway; prostaglandin; protectin; resolving.

Publication types

Review