Granulocyte viability test in children from an environment with heavy metal pollution

Acta Paediatr Hung. 1986;27(3):227-31.

Abstract

In a group of 43 school-children living near a zinc plant, the test of granulocyte viability by the method of Cocchi et al, the lead level by flame atomic absorptiometry, and the level of erythrocyte zinc-protoporphyrin by the fluorimetric method were determined in peripheral blood. The mean result of the granulocyte viability test was 6.49%. In 18 children, the proportion of abnormal granulocytes was raised abnormally above 6.0%. The lead level was in the range from 14.1 to 53 micrograms/dl, and the level of erythrocyte ZPP was from 0.3 to 2.1 micrograms/g Hb. No correlation was found between the results of the granulocyte viability test and the blood lead level. The result of a comparison with the ZPP value was of borderline significance (p = 0.05).

MeSH terms

  • Cell Survival
  • Child
  • Environmental Pollution / adverse effects*
  • Erythrocytes / analysis
  • Granulocytes / physiology*
  • Humans
  • Lead / blood
  • Protoporphyrins / blood

Substances

  • Protoporphyrins
  • zinc protoporphyrin
  • Lead