Genomic analysis of almost 8,000 Salmonella genomes reveals drivers and landscape of antimicrobial resistance in China

Microbiol Spectr. 2023 Dec 12;11(6):e0208023. doi: 10.1128/spectrum.02080-23. Epub 2023 Oct 3.

Abstract

We established the largest Salmonella genome database from China and presented the landscape and spatiotemporal dynamics of antimicrobial resistance genes. We also found that economic, climatic, and social factors can drive the rise of antimicrobial resistance. The Chinese local Salmonella genome database version 2 was released as an open-access database (https://nmdc.cn/clsgdbv2) and thus can assist surveillance studies across the globe. This database will help inform interventions for AMR, food safety, and public health.

Keywords: Salmonella; Salmonella database; antibiotic resistance genes; antimicrobial resistance; food safety; mobilome; public health; virulome.

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Anti-Infective Agents* / pharmacology
  • China
  • Drug Resistance, Bacterial / genetics
  • Genomics
  • Microbial Sensitivity Tests
  • Salmonella / genetics

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents