Possible role of miRNAs in pheochromocytoma pathology - Signaling pathways interaction

Pathol Res Pract. 2023 Nov:251:154856. doi: 10.1016/j.prp.2023.154856. Epub 2023 Oct 5.

Abstract

Pheochromocytoma (PCC) is a type of neuroendocrine tumor that originates from adrenal medulla or extra-adrenal chromaffin cells and results in the production of catecholamine. Paroxysmal hypertension and cardiovascular crises were among the clinical signs experienced by people with PCC. Five-year survival of advanced-stage PCC is just around 40% despite the identification of various molecular-level fundamentals implicated in these pathogenic pathways. MicroRNAs (miRNAs, miRs) are a type of short, non-coding RNA (ncRNA) that attach to the 3'-UTR of a target mRNA, causing translational inhibition or mRNA degradation. Evidence is mounting that miRNA dysregulation plays a role in the development, progression, and treatment of cancers like PCC. Hence, this study employs a comprehensive and expedited survey to elucidate the potential role of miRNAs in the development of PCC, surpassing their association with survival rates and treatment options in this particular malignancy.

Keywords: MiRNAs; Oncogene; PCC; Pathogenesis; Pheochromocytoma; Tumor Suppressor.

Publication types

  • Review

MeSH terms

  • Adrenal Gland Neoplasms* / diagnosis
  • Adrenal Gland Neoplasms* / genetics
  • Catecholamines
  • Humans
  • MicroRNAs* / genetics
  • Pheochromocytoma* / diagnosis
  • Signal Transduction

Substances

  • MicroRNAs
  • Catecholamines