A multi-institutional feasibility study of intra-arterial chemotherapy in children with retinoblastoma. A Children's Oncology Group study (COG ARET12P1)

Pediatr Blood Cancer. 2024 Jan;71(1):e30718. doi: 10.1002/pbc.30718. Epub 2023 Oct 10.

Abstract

Background: Intra-arterial chemotherapy (IA) as a treatment to salvage the eye with advanced retinoblastoma is increasingly utilized based on successes reported by institutions around the world mainly through retrospective studies.

Objective: To study the feasibility of delivering melphalan directly into the ophthalmic artery in a multi-institutional prospective study in children with newly diagnosed unilateral group D retinoblastoma.

Methods: The Children's Oncology Group (COG) initiated study ARET12P1 in 2014 and was open to nine institutions. Eligible patients older than six months of age were enrolled. The feasibility of delivering three injections of melphalan into the ophthalmic artery every 28 days was assessed.

Results: Nine institutions participated in this trial. Fourteen patients were enrolled, two of whom were unevaluable for feasibility. Four patients experienced a feasibility failure. In two patients, the ophthalmic artery could not be accessed for the second IA injection, in one the artery could not be accessed for the first injection, and one patient experienced grade 4 hypotension during the procedure.

Conclusion: Delivery of prescribed therapy within the context of this study did not meet the feasibility goals of the study with only a 67% feasibility success rate. These results should caution centers that plan to initiate this treatment and suggest investment in training to achieve technical expertise or referral to centers with expertise.

Keywords: Feasibility; intra-arterial chemotherapy; retinoblastoma.

Publication types

  • Multicenter Study

MeSH terms

  • Child
  • Feasibility Studies
  • Follow-Up Studies
  • Humans
  • Infant
  • Infusions, Intra-Arterial
  • Melphalan
  • Ophthalmic Artery
  • Prospective Studies
  • Retinal Neoplasms* / diagnosis
  • Retinal Neoplasms* / drug therapy
  • Retinoblastoma* / diagnosis
  • Retinoblastoma* / drug therapy
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Melphalan