Frailty in cerebellar ischemic stroke-The significance of temporal muscle thickness

Daniel Dubinski; Sae-Yeon Won; Isabell Mattes; Svorad Trnovec; Bedjan Behmanesh; Daniel Cantré; Peter Baumgarten; Nazife Dinc; Juergen Konczalla; Matthias Wittstock; Thomas M Freiman; Florian Gessler

doi:10.3389/fneur.2023.1193685

Frailty in cerebellar ischemic stroke-The significance of temporal muscle thickness

Front Neurol. 2023 Sep 26:14:1193685. doi: 10.3389/fneur.2023.1193685. eCollection 2023.

Affiliations

¹ Department of Neurosurgery, University Medicine Rostock, Rostock, Germany.
² Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medicine Rostock, Rostock, Germany.
³ Department of Neurosurgery, University Hospital, Schiller University Jena, Jena, Germany.
⁴ Department of Neurosurgery, Goethe-University Hospital, Frankfurt am Main, Germany.
⁵ Department of Neurology, University Medicine Rostock, Rostock, Germany.

^# Contributed equally.

Abstract

While comprising only 2% of all ischemic strokes, cerebellar strokes are responsible for substantial morbidity and mortality due to their subtle initial presentation and the morbidity of posterior fossa swelling. Furthermore, low temporal muscle thickness (TMT) has recently been identified as a prognostic imaging parameter to assess patient frailty and outcome. We analyzed radiological and clinical data sets of 282 patients with cerebellar ischemic stroke. Our analysis showed a significant association between low TMT, reduced NIHSS and mRS at discharge (p = 0.035, p = 0.004), and reduced mRS at 12 months (p = 0.001). TMT may be used as a prognostic imaging marker and objective tool to assess outcomes in patients with cerebellar ischemic stroke.

Keywords: cerebellar stroke; ischemic stroke; out-come; posterior fossa; risk factors; sarcopenia; temporal muscle thickness.

Grants and funding

DD received financial support from Novartis, Fresenius, Inovitro, and Novocure. The funders were not involved in the study design, collection, analysis, interpretation of data, and the writing of this article or the decision to submit it for publication.