Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology

Lindsey Dzierozynski; Jessica Queen; Cynthia L Sears

doi:10.1016/j.chom.2023.09.007

Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology

Cell Host Microbe. 2023 Oct 11;31(10):1569-1573. doi: 10.1016/j.chom.2023.09.007.

Authors

Lindsey Dzierozynski¹, Jessica Queen², Cynthia L Sears³

Affiliations

¹ Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Baltimore, MD, USA.
² Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
³ Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Bloomberg∼Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: [email protected].

Abstract

Although environmental impacts on the host microbiome have been well studied, it is less certain whether and how host genetics impact the microbiome. This commentary discusses current literature supporting host genetic influences on resident species and pathogenic microbes. Mechanistic experimental studies are warranted to understand host gene-microbiome interplay.

Keywords: cancer; colon; colorectal cancer; gut; host genes; inflammatory bowel disease; inter-kingdom interactions; microbial evolution; microbiota; mutualism.

Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology

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Abstract

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