HIV and fungal priority pathogens

Hatim Sati; Ana Alastruey-Izquierdo; John Perfect; Nelesh P Govender; Tom S Harrison; Tom Chiller; Tania C Sorrell; Felix Bongomin; Rita Oladele; Arunaloke Chakrabarti; Retno Wahyuningsih; Arnaldo Lopes Colombo; Juan Luis Rodriguez-Tudela; Chris Beyrer; Nathan Ford

doi:10.1016/S2352-3018(23)00174-1

HIV and fungal priority pathogens

Lancet HIV. 2023 Nov;10(11):e750-e754. doi: 10.1016/S2352-3018(23)00174-1. Epub 2023 Oct 9.

Authors

Affiliations

¹ Antimicrobial Resistance Division, WHO, Geneva, Switzerland.
² Mycology Reference Laboratory, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
³ Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
⁴ National Institute for Communicable Diseases, Division of the National Health Laboratory Service, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
⁵ Centre for Global Health, Institute of Infection and Immunity, St George's University of London, London, UK; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
⁶ Centers for Disease Control and Prevention, Atlanta, GA, USA.
⁷ Sydney Infectious Disease Institute, University of Sydney, Sydney, NSW, Australia.
⁸ Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.
⁹ Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
¹⁰ Doodhdhari Burfani Hospital and Research Institute, Haridwar, India.
¹¹ Department of Parasitology, Universitas Indonesia and Universitas Kristen Indonesia, Indonesia.
¹² Department of Medicine, Division of Infectious Diseases, Federal University of São Paulo, São Paulo, Brazil.
¹³ Global Action for Fungal Infections, Geneva, Switzerland.
¹⁴ Duke Global Health Institute, Duke University, Durham, NC, USA.
¹⁵ Department of Global HIV, Hepatitis and Sexually Transmitted Infections Programmes, World Health Organization, Geneva, Switzerland; Centre for Infectious Disease and Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. Electronic address: [email protected].

Abstract

The burden of invasive fungal infections associated with opportunistic fungal pathogens is a persistent challenge, particularly among people with advanced HIV disease. In October, 2022, WHO published the Fungal Priority Pathogens List (FPPL)-the first global effort to systematically prioritise fungal pathogens. Of the 19 pathogens in the WHO FPPL, four opportunistic pathogens in particular cause invasive diseases in people living with HIV: Cryptococcus neoformans, Histoplasma spp, Pneumocystis jirovecii, and Talaromyces marneffei. These four fungal pathogens are major causes of illness and death in people with advanced HIV and overwhelmingly affect those in low-income and middle-income countries. Access to diagnostics, improved surveillance, targeted support for innovation, and an enhanced public health focus on these diseases are needed in the effort to reduce HIV-associated deaths.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

HIV Infections* / complications
HIV Infections* / drug therapy
HIV Infections* / epidemiology
Histoplasma
Humans

Abstract

Publication types

MeSH terms

Grants and funding