First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia

J Pediatric Infect Dis Soc. 2023 Nov 30;12(11):581-585. doi: 10.1093/jpids/piad088.

Abstract

Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.

Keywords: HIV; HRZE; Tuberculosis; infants; pharmacokinetics.

MeSH terms

  • Adult
  • Antitubercular Agents
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • Humans
  • Infant
  • Pneumonia* / drug therapy
  • Reference Values

Substances

  • Antitubercular Agents